Melanotan II Dosage, Protocol, and Reconstitution Guide

Melanotan II/MT2

Melanotan II is a synthetic analog of alpha-MSH studied for its ability to stimulate melanin production in the skin. It is commonly discussed for tanning support, UV response, and pigmentation enhancement.

How It Works

Melanocortin Receptor Activation → Melanin Production ↑ → Skin Pigmentation ↑

Melanotan II binds to melanocortin receptors (primarily MC1R), stimulating melanin production. This increases pigmentation and may enhance the skin’s response to UV exposure.

Melanotan II Protocol

Days 1–3

Dose100 mcg

Units3 units (0.03 mL)

Days 4–7

Dose200 mcg

Units6 units (0.06 mL)

Week 2+

Dose250–500 mcg

Units8–15 units (0.08–0.15 mL)

Frequency: Once daily during loading phase
Maintenance: 1–2x weekly
Cycle Length: 2–4 weeks loading, then maintenance

Advanced Protocol

Higher Range

Dose500–1000 mcg

Higher doses are sometimes discussed but often increase side effects without significantly improving results.

When & Where to Inject

• Subcutaneous injection
• Abdomen is most common site
• Often taken in the evening to reduce side effects
• UV exposure typically paired during loading phase

Reconstitution & Dosing (10 mg Vial)

Vial 10 mg

Water 3.0 mL

Concentration 3.33 mg/mL

Conversion 1 unit = 33 mcg

Reconstitution Steps

Draw 3.0 mL bacteriostatic water

Inject slowly down vial wall

Gently swirl (do not shake)

Refrigerate immediately

Storage

Lyophilized: refrigerated or frozen

Reconstituted: 2–8°C

Use Window

Use within ~30 days

Monitoring During Use

• Skin pigmentation changes
• Freckle/dark spot development
• UV response
• Tolerance to dose

Benefits

• Increased skin pigmentation
• May reduce need for excessive UV exposure
• More even tanning response
• Potential libido increase (reported)

Potential Side Effects

• Nausea (most common early)
• Facial flushing
• Freckling or mole darkening
• Appetite suppression
• Fatigue or yawning

Stacking Strategies

• Skin Support: Melanotan II + GHK-Cu
• Recovery: Melanotan II + BPC-157
• Advanced: Combine with sun exposure protocol

Important Notes

• Start low to minimize nausea
• Effects are cumulative over time
• Monitor changes in moles or skin pigmentation
• UV exposure still plays a role in results

Important Disclaimer

Melanotan II is not FDA-approved and is intended for research purposes only.

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