MOTS-c Peptide: Dosage, Reconstitution, Protocol, and Metabolic Guide

MOTS-c Peptide

MOTS-c is a mitochondrial-derived peptide studied for its role in metabolic regulation, glucose utilization, exercise performance, and longevity pathways. It acts at the cellular energy level, influencing how the body responds to stress, insulin signaling, and metabolic demand.

What MOTS-c Supports

Mitochondria → Energy Regulation → Metabolism ↑ → Performance ↑ → Longevity Signals ↑

• Metabolic regulation
• Glucose metabolism
• Exercise performance
• Mitochondrial health
• Longevity research

Reconstitution & Dosing (10 mg Vial)

Precision Dosing → Stable Energy Signaling → Metabolic Optimization

Vial10 mg

Water3.0 mL bacteriostatic

Concentration3.33 mg/mL

Conversion1 unit = 33.3 mcg

Reconstitution Steps

Draw 3.0 mL bacteriostatic water

Inject slowly down vial wall

Gently swirl (do not shake)

Label with reconstitution date

Refrigerate at 2–8°C

Protect from light

Standard Research Protocol (Titration)

Gradual Increase → Metabolic Adaptation → Optimal Dose

Weeks 1–2

Dose200 mcg

Units6 units

FrequencyDaily

Starting Dose

Weeks 3–4

Dose400 mcg

Units12 units

FrequencyDaily

Titration

Weeks 5–6

Dose600 mcg

Units18 units

FrequencyDaily

Weeks 7–8

Dose800 mcg

Units24 units

FrequencyDaily

Weeks 9–10

Dose1000 mcg (1 mg)

Units30 units

FrequencyDaily

Target Dose

Cycle Length

• Typical: 8–12 weeks
• Extended: up to 16 weeks

Injection Method

• Subcutaneous injection
• Common sites: abdomen, thighs, upper arms
• Rotate injection sites regularly
• Use consistent timing daily

Research Dose Range

Weekly Range5–10 mg total

AdministrationSplit doses across week

Storage

• Reconstituted: 2–8°C (4–6 weeks typical)
• Some protocols: 5–7 days for max potency
• Lyophilized: up to 3 years frozen
• Refrigerated: ~2 years

Storage Precautions

• Protect from light
• Do not freeze after mixing
• Avoid room temperature exposure
• Degrades quickly outside refrigeration

Important Disclaimer

MOTS-c is an investigational compound. This content is for educational purposes only and does not constitute medical advice.

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